How much q10 to lower blood pressure

In a randomized clinical study published in Medical Science Monitor , 75 percent of statin users with muscle symptoms reported reduced pain after taking CoQ10 twice a day for 30 days, versus zero improvement in the placebo group. The researchers concluded that combining statin therapy with CoQ10 supplements could lead to higher compliance with treatment. Heart failure HF. The researchers tracked the patients for two years. After a heart attack. In a randomized clinical trial , patients who received CoQ10 soon after a heart attack had a much lower rate of subsequent cardiac events over the next year than a control group In an analysis of 12 clinical studies , researchers reported that CoQ10 has the potential to lower systolic blood pressure the top number in a blood pressure reading by up to 17 mm Hg and diastolic pressure by 10 mm Hg without significant side effects.

CoQ10 is fat-soluble and is best absorbed when taken with food. CoQ10 appears to be safe with no major side effects, except occasional stomach upset. However, researchers have not done studies and do not know if CoQ10 supplements are safe during pregnancy and breastfeeding. CoQ10 may lower blood sugar, so people with diabetes should talk with their provider before taking it to avoid the risk of low blood sugar. Some suggest that it may also lower blood pressure. If you are being treated with any of the following medications, you should not use CoQ10 without first talking to your health care provider.

Chemotherapy medications: Researchers are not sure whether CoQ10's antioxidant effect might make some chemotherapy drugs less effective. Ask your oncologist before taking antioxidants or any supplement along with chemotherapy.

Daunorubicin and doxorubicin: CoQ10 may help reduce the toxic effects on the heart caused by daunorubicin Cerubidin and doxorubicin Adriamycin , two chemotherapy medications that are used to treat several kinds of cancer. Blood pressure medications: CoQ10 may work with blood pressure medications to lower blood pressure. In a clinical study of people taking blood pressure medications, adding CoQ10 supplements allowed them to reduce the doses of these medications.

More research is needed, however. If you take medication for high blood pressure, talk to your provider before taking CoQ10, and DO NOT stop taking your regular medication. Blood-thinning medications: There have been reports that CoQ10 may make medications such as warfarin Coumadin or clopidigrel Plavix less effective at thinning the blood.

If you take blood thinners, ask your provider before taking CoQ Betaxolol Betoptic : CoQ10 supplements may reduce the heart-related side effects of betaxolol drops Betoptic , a beta-blocker medication used to treat glaucoma, without making the medication any less effective. Metabolism, ubiquinone synthesis, and longevity. Genes Dev. Beal MF. Therapeutic effects of coenzyme Q10 in neurodegenerative diseases.

Methods Enzymol. Eur Heart J. Drug Saf. Effect of coenzyme q10 on myopathyic symptoms in patients treated with statins. Am J Cardiol. Dhanasekaran M, Ren J. The emerging role of coenzyme Q in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus. Curr Neurovasc Res. Serum levels of coenzyme Q10 in patients with Alzheimer's disease.

J Neural Transm. Potential interactions between alternative therapies and warfarin. Am J Health-System Pharm. Coenzyme Q 10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. Otolaryngol Head Neck Surg. The effect of conenzyme Q10 in patients with congestive heart failure.

Ann Int Med. The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients. Minerva Gastroenterol Dietol. Conezyme Q10 and male infertility: a meta-analysis. In a double-blind study of postmenopausal women, supplementing with 10 grams of soy protein twice a day for six weeks significantly reduced diastolic blood pressure by an average of 5 mm Hg, compared with a diet not containing soy protein.

In another study, men and women with mild to moderate hypertension consumed ml approximately 16 ounces of soy milk or cow's milk twice a day for three months. After three months, the average systolic blood pressure had decreased by The reductions in diastolic blood pressure were In another study of people with hypertension who were consuming a low-protein, low-fiber diet, supplementing with a combination of soy protein and psyllium a fiber source lowered systolic blood pressure by an average of 5.

The blood pressure reduction with soy protein alone or with fiber alone was less pronounced than that with combination treatment. Other research has also shown a blood pressure—lowering effect of soy protein. In a double-blind trial, people with mild hypertension took a tincture of Achillea wilhelmsii, an herb used in traditional Persian medicine.

Participants in the trial used 15—20 drops of the tincture twice daily for six months. At the end of the trial, participants experienced significant reductions in both systolic and diastolic blood pressure compared to those who took placebo. No adverse effects were reported.

Caution: Calcium supplements should be avoided by prostate cancer patients. Calcium supplementation—typically —1, mg per day—may lower blood pressure. However, while an analysis of 42 trials reported that calcium supplementation led to an average drop in blood pressure that was statistically significant, the actual decrease was small in medical terms, a drop of 1.

Results might have been improved had the analysis been limited to studies of people with hypertension, since calcium has almost no effect on the blood pressure of healthy people.

In the analysis of 42 trials, effects were seen both with dietary calcium and with use of calcium supplements. A week trial of 1, mg per day of calcium accompanied by blood pressure monitoring is a reasonable way to assess efficacy in a given person.

Hawthorn leaf and flower extracts have been reported to have a mild blood pressure—lowering effect in people with early stage congestive heart failure. In a double-blind study, supplementation with a hawthorn extract significantly decreased diastolic blood pressure in people with type 2 diabetes.

The amount used was 1, mg per day of an extract standardized to 2. Controlled clinical trials have shown that hibiscus can lower blood pressure.

In one, people with high blood pressure who went off their medications were given either 2 teaspoons 5 to 6 grams Hibiscus sabdariffa infused in 1 cup ml water or black tea three times per day.

After 12 days the hibiscus group had significantly lower blood pressure than the black tea group. In another trial 10 grams of Hibiscus sabdariffa tea was compared to the drug captopril for four weeks in people with high blood pressure. Blood pressures fell an equal amount in both groups, suggesting this herbal tea may be as potent as some blood pressure medications.

In a double-blind study, supplementation with 2 mg of sustained-release melatonin each night for four weeks significantly reduced nighttime systolic blood pressure, compared with a placebo, in people with nocturnal hypertension. Normally, blood pressure declines at night. People with hypertension who do not have this nighttime blood pressure decline are at increased risk of developing and dying from heart disease.

Melatonin supplementation may therefore be beneficial for this subgroup of people with hypertension. In animal studies oleuropein, one of the constituents of olive leaf , has decreased blood pressure and dilated arteries surrounding the heart, when given by injection or intravenously. Olive leaf has been used traditionally to treat people with hypertension, In a double-blind trial, the blood pressure-lowering effect of an extract of olive leaf was nearly as great as that of captopril, a drug used to treat hypertension.

The olive leaf extract used in the study was EFLA , and the amount given was mg twice a day for 8 weeks. In a double-blind study of people with high blood pressure, IU of vitamin E per day taken for 27 weeks was significantly more effective than a placebo at reducing both systolic and diastolic blood pressure.

This study was done in Iran, and it is not clear whether the results would apply to individuals consuming a Western diet. The amino acid arginine is needed by the body to make nitric oxide, a substance that allows blood vessels to dilate, thus leading to reduced blood pressure. Intravenous administration of arginine has reduced blood pressure in humans in some reports.

In one controlled trial, people not responding to conventional medication for their hypertension were found to respond to a combination of conventional medication and oral arginine 2 grams taken three times per day.

Human trials investigating the use of Coleus forskohlii in blood pressure reduction have yet to be conducted. However, forskolin, the active ingredient in Coleus forskohlii, has lowered blood pressure in a small, preliminary trial with people suffering from cardiomyopathy. During the digestive process or hydroysis, egg protein is broken down into short amino acid chains.

Some of these small peptides have been found to inhibit angiotensin I-converting enzyme ACE , while others act as antioxidants in the blood vessels. These actions could lead to blood pressure reduction and improved blood vessel function. In a study looking at overweight people with high blood pressure, taking three gram servings of a protein supplement containing egg, pea, soy, and milk proteins was associated with blood pressure reductions compared to people taking a supplement with the same calorie content made with maltodextrin a carbohydrate.

After four weeks, systolic blood pressures were 4. Hemp protein is high in arginine, an amino acid that keeps blood vessels healthy and can reduce high blood pressure. There is also evidence that peptides short chains of amino acids produced through hemp protein digestion could contribute to lowering blood pressure.

In one study, the blood pressure of hypertensive rats came down after four weeks of treatment with hydrolyzed hemp protein but not after casein protein. The same study found that hydrolyzed hemp protein prevented high blood pressure from developing in young rats bred to be hypertensive. Whether hemp protein can prevent or reduce high blood pressure in humans is not known. Indian snakeroot Rauwolfia serpentina contains powerful alkaloids, including reserpine, that affect blood pressure and heart function.

Indian snakeroot has been used traditionally to treat hypertension, especially when associated with stress and anxiety.

Due to possible serious side effects, Indian snakeroot should only be taken under the careful supervision of a physician trained in its use. European mistletoe Viscum album has reduced headaches and dizziness associated with high blood pressure, according to preliminary research. Mistletoe may be taken as 0. The blood pressure-lowering effect of mistletoe is small and may take weeks to become evident. Due to possible serious side effects, European mistletoe should only be taken under the careful supervision of a physician trained in its use.

Garlic has a mild blood pressure-lowering effect, according to an analysis of ten double-blind trials. All of these trials administered garlic for at least four weeks, typically using — mg of garlic extract per day. A double-blind trial reported that reishi mushrooms significantly lowered blood pressure in humans.

The trial used a concentrated extract of reishi in the amount of 55 mg three times per day for four weeks. It is unclear from the clinical report how long it takes for the blood pressure-lowering effects of reishi to be measured.

A deficiency of the amino acid taurine , is thought by some researchers to play an important role in elevating blood pressure in people with hypertension.

Limited research has found that supplementation with taurine lowers blood pressure in animals and in people at 6 grams per day , possibly by reducing levels of the hormone epinephrine adrenaline. Interactive effect of cigarettes and coffee on daytime systolic blood pressure in patients with mild essential hypertension.

J Hypertens ; Alcohol, blood pressure and hypertension. Novartis Round Symp ; [review]. Physical training of middle-aged men with borderline hypertension. Ann Clin Res ;14 Suppl 34 The effect of aerobic exercise and T'ai Chi on blood pressure in older people: results of a randomized trial. J Am Geriatr Soc ; Progressive resistance exercise and resting blood pressure.

A meta-analysis of randomized controlled trials. Hypertension ; Alderman MH. Nonpharmacologic approaches to the treatment of hypertension. Lancet ; [review]. Ann Intern Med ; Long-term effects of weight loss and dietary sodium reduction on incidence of hypertension.

Journal of Human Hypertension 21, ; doi Psychological predictors of hypertension in the Framingham Study. Is there tension in hypertension? JAMA ; Relation between job strain, alcohol, and ambulatory blood pressure.

Stressful work conditions and diastolic blood pressure among blue collar factory workers. Am J Epidemiol ; Pickering TG.

Does psychological stress contribute to the development of hypertension and coronary heart disease? Suppressed aggression accelerates early development of essential hypertension. Key Results Pooled data from two trials showed that coenzyme Q10 did not affect blood pressure compared to placebo.

Quality of the Evidence This review provides moderate-quality evidence that coenzyme Q10 does not lower blood pressure.

Authors' conclusions:. To determine the blood pressure lowering effect of coenzyme Q10 in primary hypertension. Search strategy:. Selection criteria:. Data collection and analysis:. Main results:. Health topics:.